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KMID : 0605620080150040254
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Journal of Korean Society of Biological Psychiatry
2008 Volume.15 No. 4 p.254 ~ p.264
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Neural Substrates of Fear Based on Animal and Human Studies
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Baek Kwang-yeol
Jeong Jae-Seung
Park Min-Sun
Chae Jeong-Ho
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Abstract
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Objectives：The neural substrate of fear is thought to be highly conserved among species including human. The purpose of this review was to address the neural substrates of fear based on recent findings obtained from animal and human studies.
Methods：Recent studies on brain regions related to fear, particularly fear conditioning in rodents and humans,
were extensively reviewed.
Results：This paper suggests high consistency in anatomical structure and physiological mechanisms for fear
perception, response, learning and modulation in animals and humans.
Conclusions：Fear is manifested and modulated by well conserved neural circuits among species interconnected with the amygdala, such as the hippocampus and the ventromedial prefrontal cortex. Further research
is required to incorporate findings from animal studies into a better understanding of neural circuitry of fear in human in a translational approach.
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KEYWORD
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Fear, Fear conditioning, Amygdala, Neuroanatomy, Translational neuroscience.
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